Dioscorea villosa (Wild Yam Root)
Wild Yam extract is known to be an anti-inflammatory and antispasmodic agent.

Contrary to popular belief, wild yam roots do not contain hormones. There is no way for the human body to convert wild yam root into progesterone, dehydroepiandrosterone (DHEA), or other hormone. This can lead to confusion. While wild yam can be a source of progesterone after being processed, it cannot be converted into progesterone by the body.

Wild Yam Root is used in Migraine Defense for its ability to aid in managing the equilibrium of hormones as well as its ability to decreases the inflammatory response of the cerebral neurovascular system to abate vasospasm's frequently experienced during a migraine episode.