Migraine Defense works on the cause of a migraines.
• Blocks production of migraine producing chemicals
• Manages migraine gene centers proteins
• Breaks migraine patterns including rebound headaches
• Creates biological defense against future migraines
Cause of Migraine
During the past ten years, migraine researchers have discovered the
genetics of migraines (migraine genes) and acknowledged the hormone connection
to occurrence of migraines.
We can safely say that most migraines occurring in men, women, and children are
caused by how the body manages the changes in hormone production.
That is just the tip of the iceberg in understanding the process that goes
on in the body to cause a migraine to occur. Although most migraines actually
occur as part of a pattern, migraines can and do occur at unpredictable times
and for any number of varying reasons.
After years of studying migraines, the researchers at Tuliv discovered
how the factors involved in igniting and sustaining the
intensity of a migraine including the chemical reactions, migraine gene,
specific hormones involved, receptor proteins, and external
triggers work in the body to cause migraines. Understanding the interaction of
these factors enabled the development of the first migraine prevention product
designed to defend against the actual cause of migraines, i.e. Tuliv Migraine
Chemical Reactions are the Keys to Migraines. Although
a migraine can be triggered internally or by an outside force, the actual mechanism
that causes a migraine headache is a combination of chemical reactions and synthesizing
that eventually results in the production and release of a neurochemical called
is the chemical that causes the swelling of the blood vessels that are intertwined
with tiny nerve endings of the trigeminal nerve located on both sides of the
head and as this occurs the result is a painful migraine headache with associated
aura, nausea and vomiting.
Approach to Migraine Prevention
Controlling the production of the CGRP neurochemical is the proper
approach to migraine prevention. Tuliv
was developed on this premise and has used this approach
in its product formula for migraine prevention since 2004. In recent news
(October 19, 2011) Arteaus, a biotechnology development company
(in association with Eli Lilly) has announced that it has
decided this is the proper approach to migraine prevention and is attempting
to develop a product that attacks the cause of migraine as defined by Tuliv.
This again validates the research of Tuliv and its founders. Thus far no other
migraine prevention product or drug has been developed to the extent of Migraine
Defense in using this scientific approach.
reason some people get migraines can be found in the DNA makeup as an inherited
gene. This gene has been identified and labeled as MTHFR and is found in the
mitochondria of specific cells. These cells are the hormone producing cells for
estrogen and progesterone for both men and women (yes, men produce the same hormones
cells receive their “production” orders by way of other
hormones known as “messenger” hormones that are produced and secreted
by the pituitary gland. The way these cells know that the messenger hormones
are for them is through specialized proteins that are on the outside of the cell
membrane called hormone receptors.
What Controls the Migraine Pattern?
understanding as to where and how migraines start can be found in studying
the path of a migraine from the beginning.
Migraines occur when various hormone levels of
the body fluctuate and most often when the "messenger" hormones
are secreted from the pituitary gland into the blood stream to be received by
the aforementioned specific cells in the body that have the migraine gene. For
a still unknown reason, there is an adverse reaction in these cells that causes
the production of neurochemical identified as CGRP to occur.
How Do Hormones Cause Migraines?
Hormones don’t in the true sense of cause and effect; however, when
we use the analogy of an automobile we can start to understand the relationship.
Gasoline, for example does not make the car go; rather, gasoline makes the engine
run which rotates the transmission gears, which make the wheels turn. Hormones
are like the gasoline in that they start a reaction which results in the wheels
turning that ends with a migraine.
To say that estrogen or progesterone is the cause of a migraine is a misunderstanding
of the effect of hormones on migraines. This misunderstanding has led to the
prescribing additional hormones as a treatment for migraines. We can readily
see the adverse effect of hormones on migraine when we realize that birth control
pills, which are hormones, generally cause migraine headaches.
Mechanics of a Migraine Migraines
occur outside the brain in what is called the trigeminal nerve vascular system.
Those who have had migraine headaches can easily draw the path of this system
as it starts at the temples and runs forward to branch out behind the eyes and
down the jaw line. This system is comprised of hair-like nerve fibers that are
intertwined with tiny blood vessels.
pain of a migraine headache occurs when these tiny blood vessels dilate and begin
to swell and expand to the point where they are actually putting pressure on
the nerve endings. We often feel throbbing pain as the blood fills these vessels
and pinch on nerves.
is the neurochemical CGRP that causes the blood vessels to dilate
and expand. To make
matters worse, when the nerve fibers become irritated, they react in a way that
can cause an increase in the level of CGRP in a round-robin effect that increases
the pain level and the duration of a migraine attack.
To learn more see the Tuliv
Hormone Patterns Become Migraine Patterns
It is easier to see the hormonal cause of migraines in women than in men because of the monthly menstrual cycle of women, even though the principle and hormones are exactly the same for men and women.
Menstrual cycles are controlled by the pituitary gland. Remember this is the
gland we have been talking about that secretes the messenger hormones that are
received by the cells that contain the migraine gene that starts the production
of the neurochemical involved in migraines.
There is nothing wrong with the pituitary
gland or the hormones; rather, it is what occurs after these hormones, mainly
LH and FSH for both men and women, are received by the specialized cells that
contain the migraine gene.
Migraine Patterns Tuliv research found that migraine attacks directly
correlate with the patterns of hormone secretions that occur in the body at various
times of day, during the course of a month, and at various stages of life. For
more information, see Migraine
We have talked mainly about hormones
from the pituitary gland. Tuliv research has also identified two other glands
and hormones involved in triggering migraines, namely the pineal gland secreting
melatonin and the adrenal gland secreting cortisol. We have found melatonin to
be involved in migraines that occur around 4 AM and also around 4 PM, whereas,
cortisol is related to stress headaches and perhaps morning migraines.
Natural Cause - Natural Solution
Understanding how hormones are involved in migraines and their effect on migraine
patterns provided the insight needed for the development of the first and only
migraine preventive that addresses the natural cause of migraines - Tuliv
Tuliv Migraine Defense is an all-natural formula that works on the natural
cause of migraines.
Tuliv® and Migraine Defense® are registered trademarks of Tuliv Ltd. Co.
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